Analgesic and anti-inflammatory activity of a polyherbal formulation (PHF-AROGH) > Volume 09 - 2009

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Oriental Pharmacy and Experimental Medicine
Volume 09 - 2009
Date: May 21, 2008

Journal: Pages 232-237

September 2009 | Analgesic and anti-inflammatory activity of a polyherbal formulation (PHF-AROGH)…

M Mohan1,*, VS Gulecha1, VM Aurangabadkar1, R Balaraman2, A Austin3 and S Thirugnanasampathan3

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Summary

​The effect of arogh, a polyherbal formulation-PHF [each 3 g powder contained Nelumbo nuciferaG. (0.24 g), Hemidesmus indicus R. (0.24 g), Zingiber officinale R. (0.24 g), Terminalia chebula R.(0.24 g), Quercus infectoria O. (0.12 g), Hibiscus rosa-sinensis L. (0.24 g), Rosa damascene M.(0.24g), Eclipta alba H.(0.24 g), Glycyrrhiza glabra L. (0.24 g)] was investigated in various experimentalmodels of pain and inflammation. Analgesic activity of PHF was studied in mice using acetic acidinduced writhing, tail immersion and hot plate methods. Anti-inflammatory activity of PHF wasstudied in rats using carrageenan induced hind paw edema and formalin induced rat paw edemamethods. PHF significantly (P < 0.05) reduced the number of writhings, increased latency to flicktail in tail immersion method and elevated the mean basal reaction time in hot plate method. PHFsignificantly (P < 0.05) inhibited carrageenan induced hind paw edema and formalin induced ratpaw edema. The PHF was tested at dose of 30, 100, 300 and 500 mg/kg.


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