Gymnosporia rothiana (walp) Lawson (celastraceae), commonly known as Maytenus rothiana, isused in Indian folk medicine as an antiulcerogenic agent. However, there have been no scientificreports regarding its antiulcer activity. Therefore, this study was intended to evaluate the antiulcerproperty of petroleum ether, chloroform, and methanolic extract of leaves of Gymnosporia rothianaat different dose levels in ethanol induced and indomethacin induced gastric ulcer models. It wasobserved that oral administration of all the extract of Gymnosporia rothiana produces significantreduction in ulcer lesion index as well as increase in volume and pH of gastric content in bothexperimental models, being petroleum ether extract the most effective at dose of 250 mg/kg; itsignificantly reduced gastric lesion index (70.06%), in comparison to omeprazole (71.20%) andmethanolic extract at a dose of 500 mg/kg (67.22%). Increased gastric mucosal defense mechanism bypetroleum ether extract is probably due to its high levels of terpenoids like β amyrin, lupeolacetate. The present results clearly shows antiulcer effect of Gymnosporia rothiana against variousirritants has been mainly due to cytoprotective effect mediated through prostaglandin and partlydue to free radical scavenging activity.