Effect of curcumin in the prevention of experimentally induced nephrolithiasisin rats by ethylene glycol and Vitamin D3 > Volume 09 - 2009

본문 바로가기

사이트 내 전체검색


 » New Articles(2011~Present)
 » Articles (2001~2010)
      ∙ Volume 10 - 2010
      ∙ Volume 09 - 2009
      ∙ Volume 08 - 2008
      ∙ Volume 07 - 2007
      ∙ Volume 06 - 2006
      ∙ Volume 05 - 2005
      ∙ Volume 04 - 2004
      ∙ Volume 03 - 2003
      ∙ Volume 02 - 2002
      ∙ Volume 01 - 2001
 

Oriental Pharmacy and Experimental Medicine
Volume 09 - 2009
Date: July 08, 2008

Journal: Pages 259-267

September 2009 | Effect of curcumin in the prevention of experimentally induced nephrolithiasisin rats by ethylene glycol and Vitamin D3…

Chintan N Gandhi and R Balaraman*

첨부파일

Summary

​Curcumin (CMN) is known to have beneficial role in anorexia, coryza, cough, diabetic wounds,and hepatic disorders apart from its inherent antioxidant effects. Therefore, the present study wasaimed to evaluate antioxidant effect of CMN in prevention of nephrolithiasis in rats-induced byethylene glycol (EG) and Vitamin D3 (Vit. D3). Male Wistar rats (175 - 200 g) were randomized ingroups like control, EG + Vit. D3 induced nephrolithiatiatic rats, CMN treated rats, CMN + EG +Vit. D3 treated rats, Vit. E + EG + Vit. D3 treated rats. Urine was collected weekly throughout theexperimental protocol and estimated for calcium oxalate (CaO) count. After completion ofexperimental protocol serum was estimated for blood urea nitrogen and creatinine. Both thekidneys were excised and used to evaluate levels of biomarkers of oxidative stress and calciumoxalate crystal deposition by histopathological studies. Administration of EG and Vit. D3 to ratsresulted in increased oxidative stress, hyperoxaluria and renal deposition of CaO crystals.Supplementation with CMN improves kidney function, reduces elevated oxidative stress, urinaryoxalate level and renal deposition of CaO which shows its protective action in nephrolithiasis.The increased deposition of stone in the kidney and stone forming constituents of nephrolithiaticrats were effectively lowered by treatment of CMN.


This website Copyright (c) 2014 Institute of Korean Medicine Kyung Hee University All rights reserved.
Top View
Mobile View