An attempt has been made to assess whether the dose dependent effect of benzene extract ofOcimum sanctum leaves on the morphological changes in the cauda epididymal spermatozoa andsperm parameters in male albino rats. Scanning Electron Microscope observations illustrate thedisturbance in plasma membrane as well as acrosomal membrane. Most of the sperms appearmorphologically abnormal in the mid region of the tail; there is formation of balloon likecytoplasmic droplet. Sperm parametric study exhibits decrease in the total sperm count, spermmotility, forward velocity and increase in the percentage of abnormal sperms in dose dependentmanner on treatment benzene extract of Ocimum sanctum leaves. The results suggest that theeffects may have resulted from a general disturbance in the proteins and alteration in caudaepididymal milieu probably due to androgen deficiency consequent upon antiandrogenicproperty of Ocimum sanctum leaves.