Hepatoprotective activity of terpenoids and terpenoid fractions of Scopariadulcis L > Volume 10 - 2010

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Oriental Pharmacy and Experimental Medicine
Volume 10 - 2010
Date: March 10, 2009

Journal: Pages 263-270

December 2010 | Hepatoprotective activity of terpenoids and terpenoid fractions of Scopariadulcis L…

Praveen Thaggikuppe Krishnamurthy1,*, Jitendra Bajaj1, Abhishek Sharma1, Sellappan Manimaran1,Prashantha Kumar Bommenahalli Ravanappa2 and Vijayan Pottekad3



​Scoparia dulcis L. is widely used in the traditional system of medicine for treating liver ailments. Inthe present study the terpenoids and terpenoid fractions isolated from 1:1:1 petroleum ether,diethyl ether and methanol (PDM) extract of Scoparia dulcis L. were tested for their in vitro 1, 1-Diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity. Selected samples from the assaywere further tested for their in vitro hepatoprotective activity against CCl4 induced hepatotoxicityin freshly isolated rat hepatocytes. In the in vitro antioxidant study, fractions 7, 11, 13, 14, and 15and PDM extract show the DPPH radical scavenging activity. The phytochemical screening of allthese fractions show the presence of terpenoids. In the in vitro hepatoprotective study all thesefractions and the PDM extract significantly prevent the CCl4 induced changes in the aspartateaspartate amino transferase, alanine amino transferase and alkaline phosphatase levels (p < 0.05).The above results are comparable with the standard, silymarin. The results of the study indicatethat, the PDM extract of Scoparia dulcis L. possesses potential hepatoprotective activity and thismay be attributed to its free radical scavenging potential, which in turn may be attributed to thepresence of terpenoids.

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