Lindera erythrocarpa Makino extract reduces obesity induced by high-fatdiet in rats > Volume 10 - 2010

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Oriental Pharmacy and Experimental Medicine
Volume 10 - 2010
Date: September 15, 2010

Journal: Pages 288-293

December 2010 | Lindera erythrocarpa Makino extract reduces obesity induced by high-fatdiet in rats…

Meejung Ahn1, Wonjun Yang2, Sohi Kang2, Min-Chul Kang3, Ryeo Kyeong Ko3, Gi-Ok Kim3,# andTaekyun Shin2,*

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Summary

​Lindera erythrocarpa Makino (LE) is widely distributed on Jeju Island, where it has been used forvarious traditional therapies. Effects of a crude extract of LE were examined in rats with obesityinduced by a high-fat diet (HFD). Anti-obesity effects were followed in rats receiving orallyadministered vehicle, 100mg/kg extract, or 250 mg/kg LE extract, for 56 days. LE extract (250mg/kg) suppressed increases in body weight and epididymal fat, with amelioration of fatty changes in theliver. Additionally, serum levels of alanine aminotransferase, aspartate aminotransferase, andtotal cholesterol were significantly decreased compared with those of vehicle-treated groups (p <0.05). These results suggest that oral administration of LE extract reduced rat obesity induced byHFD, possibly through the reduction of fat accumulation.


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