A comparative study of radioprotection with Callophyllis japonica extract andamifostine against lethal whole body gamma irradiation in mice > Volume 10 - 2010

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Oriental Pharmacy and Experimental Medicine
Volume 10 - 2010
Date: February 03, 2010

Journal: Pages 1-6

March 2010 | A comparative study of radioprotection with Callophyllis japonica extract andamifostine against lethal whole body gamma irradiation in mice…

Taekyun Shin1,2,*, Heechul Kim1,2, Jeongtae Kim1,2, Meejung Ahn1,2, Changjong Moon3, Jin WonHyun2,4, Youngheun Jee1,2, Nam Ho Lee 2,5 and Jae Woo Park2,6

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Summary

​The efficacy of the radioprotective effect of Callophyllis japonica ethyl acetate (CJEA) extract wasstudied by comparing it to that of amifostine, a well-known radioprotective agent, and byevaluating the dose reduction factor, an indicator of radioprotective efficacy. Pretreatment withCJEA extract (100 mg/kg body weight) prior to receiving 12 Gy irradiation significantly improved thesurvival of jejunal crypts at 3.5 day post-irradiation, but attenuated the level of malondialdehydecompared to vehicle alone (P < 0.01). A similar gastroprotective effect was also obtained in theamifostine-treated irradiated group (P < 0.01). The efficacy of the radioprotective effect wasfurther confirmed by the dose reduction factor, 1.41. Collectively, these results suggest that CJEAextract is a useful radioprotectant whose efficacy is similar to that of amifostine and whoseradioprotective mechanism is in part the reduction of lipid peroxidation caused by gammairradiation.


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