Anti-ulcer and antioxidant activity of leaves of Madhuca indica in rats > Volume 10 - 2010

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Oriental Pharmacy and Experimental Medicine
Volume 10 - 2010
Date: May 23, 2009

Journal: Pages 13-20

March 2010 | Anti-ulcer and antioxidant activity of leaves of Madhuca indica in rats…

GU Chidrewar, JH Tanavade, SH Deshpande, PS Vartak, JB Shah, NP Patel, CR Patadiya and PABafna*



​The leaves of Madhuca (M.) indica J.f.Gmel. (Sapotaceae) have been used traditionally in folkmedicine due to its astringent properties and are effective in treatment of eczema and snake bites.Methanolic extract of M. indica is rich in tannins and has been proven experimentally to possessantibacterial activity. The present study was undertaken to evaluate the anti-ulcer andantioxidant activity of M. indica in rats. The methanolic extract of leaves of M. indica was tested atvarious doses (75, 150 and 300 mg/kg, p.o.) for its effect on gastric secretion and gastric ulcers inpylorus-ligation and on ethanol- induced gastric mucosal injury in rats. The significant reductionin ulcer index in both the models along with an increase in the pH of the gastric fluid and mucincontent of stomach, and the acid secretory parameters such as total acidity and volume of gastricfluid were also significantly reduced along with reduction in the pepsin activity in pylorus-ligated rats proved the anti-ulcer activity of M. indica. The increase in the levels of superoxidedismutase, catalase and reduced glutathione and decrease in lipid peroxidation in both themodels proved the antioxidant activity of M. indica. Thus it can be concluded that M. indicapossesses anti-ulcer activity, which can be attributed to its antioxidant mechanism of action.

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