Palmitic acid inhibits inflammatory responses in lipopolysaccharide-stimulated mouse peritoneal macrophages > Volume 10 - 2010

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Oriental Pharmacy and Experimental Medicine
Volume 10 - 2010
Date: February 09, 2010

Journal: Pages 37-43

March 2010 | Palmitic acid inhibits inflammatory responses in lipopolysaccharide-stimulated mouse peritoneal macrophages…

Ju Young Lee1, Hye Ja Lee1, Ji Ahn Jeong1 and Ji Wook Jung2,*

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Summary

​Palmitic acid (PA) is one of free fatty acids, which is found from Gaultheria itoana Hayata andSarcopyramis nepalensis. Although PA has a variety of pharmacological effects including mediateshypothalamic insulin resistance, induces IP-10 expression, and promote apoptotic activities, theanti-inflammatory mechanism of PA in mouse peritoneal macrophages remains unclear. In thisstudy, we showed that PA exerted an anti-inflammatory action through suppression theproduction of tumor necrosis factor-α, interleukin-6, cyclooxygenases-2 and nitric oxide inlipopolysaccaride-stimulated mouse peritoneal macrophages. Our study suggests an importantmolecular mechanism of PA, which might explain its beneficial effect in the regulation ofinflammatory reactions.


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