Effects of Vitex rotundifolia on radical scavenging and nitric oxide production > Volume 10 - 2010

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Oriental Pharmacy and Experimental Medicine
Volume 10 - 2010
Date: March 10, 2010

Journal: Pages 51-58

June 2010 | Effects of Vitex rotundifolia on radical scavenging and nitric oxide production…

Jae Ki Choi1, Dong Seok Cha1, Yong Jae Lee1, Sung Hoon Ko1, Ho Jun Park1, Se Yeoun Lee1,Jae Hyuk Choi1 and Hoon Jeon1,2,*

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Summary

​Vitex rotundifolia (V. rotundifolia) has been used for treating headache, dizziness, toothache andremoval of fever as a traditional medicine in Korea. In the present study, we examined theantioxidant and anti-inflammatory activities of 85% methanol extract of V. rotundifolia. In variousradical scavenging assays, V. rotundifolia exhibited strong scavenging effect on 1, 1-diphenyl-2-picrylhydrazyl free radical, superoxide radical, nitric oxide. To elucidate the anti-inflammatoryproperties of V. rotundifolia, we investigated the inhibition effects of nitric oxide production inIFN-gamma and LPS-stimulated mouse peritoneal macrophages. V. rotundifolia suppressed nitricoxide production, iNOS and COX-2 expression dose-dependently through suppression of NF-êBactivation without notable cytotoxicity. These findings mean that V. rotundifolia may be beneficialin oxidative stress-mediated inflammatory disorders.


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