Antihyperglycemic and lipid lowering effect of Tectona grandis in alloxaninduced diabetic rats > Volume 10 - 2010

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Oriental Pharmacy and Experimental Medicine
Volume 10 - 2010
Date: June 30, 2010

Journal: Pages 59-66

June 2010 | Antihyperglycemic and lipid lowering effect of Tectona grandis in alloxaninduced diabetic rats…

Ghaisas MM1,*, Navghare VV2, Takawale AR2, Zope VS2, Tanwar MB2 and Phanse MA2

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Summary

​In India, Tectona grandis is traditionally used in the treatment of diabetes mellitus and lipiddisorder. In the present study, the antihyperglycemic and lipid lowering effect of ethanolic extractof bark of Tectona grandis (TG) was evaluated using alloxan induced diabetes in rats. Alloxan wasgiven at the dose of 140 mg/kg, i.p. After induction of diabetes, TG was administered for 42 daysp. o. and simultaneously different biochemical parameters like plasma glucose, liver glycogencontent, serum triglyceride, cholesterol, LDL-cholesterol and HDL-cholesterol were estimated.Diabetic control showed significant increase (P < 0.01) in plasma glucose, serum triglyceride,cholesterol, LDL-cholesterol and significant decrease (P < 0.01) in serum HDL-cholesterol andliver glycogen content. Treatment with TG showed significant reduction (P < 0.01) in plasmaglucose when compared with diabetic control. The elevated levels of serum triglyceride andcholesterol levels were significantly reduced (P < 0.01) by TG. TG treatment for 42 days showedsignificant decrease in serum LDL-cholesterol (P < 0.01) and significant increase in serum HDL-cholesterol level (P < 0.01). Moreover, diabetic control there was significant decrease in liverglycogen content which was significantly increased (P < 0.05) by treatment with TG. Hence, fromthe result obtained in the present study it can be concluded that Tectona grandis has the potentialto treat diabetes condition and associated lipid disorder.


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