Assessment of free-radical-scavenging and antibacterial activities, andbrine shrimp toxicity of Scutellaria pinnatifida (Lamiaceae) > Volume 10 - 2010

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Oriental Pharmacy and Experimental Medicine
Volume 10 - 2010
Date: March 22, 2010

Journal: Pages 304-309

December 2010 | Assessment of free-radical-scavenging and antibacterial activities, andbrine shrimp toxicity of Scutellaria pinnatifida (Lamiaceae)…

Severine Sauvage1, Emilie Samson1, Melanie Granger1, Anisha Majumdar1, Poonam Nigam1, LutfunNahar2, Sezgin Celik3 and Satyajit D. Sarker4,*

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Summary

​Scutellaria pinnatifida A. Hamilt. (Lamiaceae) is an endemic Turkish herb. This plant is also endemic toIran, and grows abundantly in other central and western Asian countries. Several species of theScutellaria are known for their traditional uses in the treatment of hypertension, arteriosclerosis,inflammatory diseases, hepatitis, allergy, cancer and diarrhoea. Free-radical-scavenging property,antibacterial activity and brine shrimp toxicity of the n-hexane, dichloromethane (DCM) andmethanol (MeOH) extracts of S. pinnatifida were assessed using the 2,2-diphenyl-1-picryl-hydrazyl(DPPH) assay, the resazurin microtitre plate based assay, and the brine shrimp lethality assay,respectively. The DCM and MeOH extracts exhibited free-radical-scavenging property, with theRC50 values of 0.362 and 0.127 mg/ml, respectively. Among the solid-phase extraction fractions ofthe MeOH extract, the 50% aqueous-MeOH fraction showed the highest level of free-radical-scavenging activity (RC50 = 0.039 mg/ml). While the DCM extract showed low level of antibacterialactivity against Bacillus subtilis and ampicillin-resistant Escherichia coli, the MeOH extract wasactive against B. cereus, B. subtilis, E. coli and ampicillin-resistant E. coli. However, the minimuminhibitory concentrations (MIC) of the MeOH extract against these bacterial strains were >10 mg/ml.None of the extracts showed any significant toxicity towards brine shrimps (LD50 = > 1.00 mg/ml).


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