Effect of ethanol (ASE) and water (ASW) extracts of Argyreia speciosa on blood glucose and lipidprofile was investigated in normoglycemic and Streptozotocin (STZ)-induced diabetic animals. Inoral glucose and sucrose tolerance test, treatment with ASE and ASW (100 and 200 mg/kg) andGlidenclamide (10 mg/kg) significantly improved the glucose and sucrose tolerance in normalanimals. In addition, respective treatment for fifteen-day resulted in significant percentagereduction in serum glucose (SG) ie., 30.39% (lower dose of ASE) and 33.21% (higher dose ofASW). In standardized STZ (50 mg/kg, iv)-induced diabetic rats, a single dose of ASE and ASWtreatment exhibited reduction in SG levels at different time intervals compared to basal levels.Administration of both the doses of ASE and ASW for fifteen-day days exhibited greaterpercentage reduction in glycemia (24.6%, 24.7%, 23.9% and 21.9% respectively) and also amelioratedrestored to near normal value of all tested lipid parameters. Further, treatment also exhibitedsignificantly improved glucose tolerance over the period of 120 min compared to diabetic controlgroup. Eventhough treatment failed to increase serum insulin levels significantly but peripheralutilization of insulin was increased as evident by insulin tolerance test. Taken together, presentstudy supports the traditional usage of title plant in the treatment of diabetes mellitus.