Dolichos biflorus Linn attenuate progression of renal damage in alloxan-induced diabetic rats > Volume 10 - 2010

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Oriental Pharmacy and Experimental Medicine
Volume 10 - 2010
Date: June 30, 2010

Journal: Pages 134-140

June 2010 | Dolichos biflorus Linn attenuate progression of renal damage in alloxan-induced diabetic rats…

GU Chidrewar1, VS Mane1, MM Ghaisas2,* and AD Deshpande1

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Summary

​Dolichos biflorus Linn. (Fabaceae), commonly known as Horse gram is a medicinal plant, used infolk medicine for treating kidney stones and diabetes mellitus. The purpose of the present studywas to investigate the effects of daily oral feeding of various doses of methanolic extract ofDolichos biflorus seeds (DB) for 42 days on blood glucose concentrations and kidney functions inAlloxan-diabetic rats. Plasma glucose levels, body weight, serum creatinine, and urinary albuminlevels were monitored on 15th, 29th, 43rd day. Renal hypertrophy was assessed as the ratio betweenthe kidney weight and body weight of the rats. Plasma glucose concentrations in Alloxan-diabeticrats were significantly reduced by the administration of DB (350 mg/kg) and DB (700 mg/kg) onday 15 and onwards (P < 0.01). After 15 days of Alloxan administration urinary albumin levels(UAE) were over 5 fold higher in diabetic controls as compared to normal controls. Treatmentwith DB significantly prevented the rise in UAE levels from day 15 to 43 in comparison to diabeticcontrols (P < 0.01). Renal hypertrophy was significantly higher in diabetic controls as comparedto non-diabetic controls. Treatments with DB (350 mg/kg) and DB (700 mg/kg) significantlyprevented renal hypertrophy (P < 0.01) as compared to diabetic controls. DB (175 mg/kg) failed tomodify renal hypertrophy. Thus the present study indicates that methanolic extract of Dolichos biflorusmay be useful in management of hyperglycemia and kidney functions in Alloxan-diabetic rats.


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