Anti-inflammatory and radical scavenging properties of Verbena officinalis > Volume 10 - 2010

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Oriental Pharmacy and Experimental Medicine
Volume 10 - 2010
Date: November 5, 2010

Journal: Pages 310-318

December 2010 | Anti-inflammatory and radical scavenging properties of Verbena officinalis…

Hwan Ki Shim, Seong Yeol Kim, Borim Kim, Jae Park Cho, Yae Jeong Park, Won Geun Ji, DongSeok Cha and Hoon Jeon*

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Summary

​Verbena officinalis (Verbenaceae) has been used as herbal medicine or health supplement in bothWestern and Eastern countries for centuries. In the present study, we examined the anti-inflammatory and antioxidant activities of the methylene chloride fraction of V. officinalis (VMC).To elucidate the anti-inflammatory properties of VMC, we investigated the inhibition effects ofnitric oxide production in interferon-gamma (IFN-γ) and lipopolysaccharide-stimulated mouseperitoneal macrophages. VMC suppressed nitric oxide production, inducible nitric oxide synthase andcyclooxygenase-2 expression dose-dependently without notable cytotoxicity. In various radicalscavenging assays, VMC exhibited strong scavenging effect on DPPH radical, superoxide radical,nitric oxide radical and 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid) radical. VMC alsoshowed potent reducing power. These findings strongly suggest that VMC may be beneficial inoxidative stress-mediated inflammatory disorders.


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